Lthough Epileptic Disorders Are Similar in Males and Females, Special Issues Are Female Specific

and females, special issues are female specific.1 Significant social and physiological differences between males and females require a modified approach towards female patients.1,2 This approach should consider a variety of factors such as age, relationships, diagnosis, female specific syndromes, the influence of female sex hormones and cosmotic effects of anti-epileptic drugs.1-3 Epilepsy and gender. Epilepsy predominates in men except in adolescence, and the elderly population.1 Explanations for epilepsy male preponderance include increased head trauma as an epilepsy risk factor in males in comparison to females, epilepsies without generalized tonic clonic seizures are often ignored by women in some cultures and the female brain is less vulnerable to perinatal anoxia in the intrauterine life with some evidence that male and female sex hormones have a differential effect on brain development.4 Few epileptic syndromes occur exclusively in females such as Rett syndrome (a neurodevelopmental disorder with neurological and cognitive regression, intractable epilepsy and autistic behavior), Aicardi A